IUPAC: 1-(1,2-Diphenylethyl)piperidine

 

Summenformel: C19H23N

 

CAS-Nummer: 36794-52-2 

 

Reinheitsgrad: ?98%

 

Beschreibung: Diphenidine (1-(1,2-diphenylethyl)piperidine) is a dissociative anesthetic drug that has been sold online as a research chemical.[1] The synthesis of diphenidine was first reported in 1924, and employed a nitrile displacement reaction analogous to the one that would later be used to discover phencyclidine in 1956.[1] Shortly after the 2013 UK ban on arylcyclohexylamines, diphenidine and the related compound methoxphenidine became available on the gray market.[1] Anecdotal reports describe high doses of diphenidine producing "bizarre somatosensory phenomena and transient anterograde amnesia."[1] Diphenidine and related diarylethylamines have been studied in vitro as treatments for neurotoxic injury and are antagonists of the NMDA receptor.[2][3][4] Recent electrophysiological analysis demonstrates that the amplitude of NMDA-mediated fEPSPs are reduced by diphenidine and ketamine to a similar extent, with diphenidine displaying a slower onset of antagonism.[4] Though vendors of diphenidine have stated the compound "acts on dopamine transport" to date diphenidine has not been screened for affinity at the dopamine transporter.[1] In dogs diphenidine exhibits greater antitussive potency than codeine phosphate.[5]